An autoimmune response to odorant binding protein 1a is associated with dry eye in the Aire-deficient mouse.

نویسندگان

  • Jason J DeVoss
  • Norbert P LeClair
  • Yafei Hou
  • Navdeep K Grewal
  • Kellsey P Johannes
  • Wen Lu
  • Ting Yang
  • Craig Meagher
  • Lawrence Fong
  • Erich C Strauss
  • Mark S Anderson
چکیده

Sjögren's Syndrome (SS) is a human autoimmune disease characterized by immune-mediated destruction of the lacrimal and salivary glands. In this study, we show that the Aire-deficient mouse represents a new tool to investigate autoimmune dacryoadenitis and keratoconjunctivitis sicca, features of SS. Previous work in the Aire-deficient mouse suggested a role for alpha-fodrin, a ubiquitous Ag, in the disease process. Using an unbiased biochemical approach, however, we have identified a novel lacrimal gland autoantigen, odorant binding protein 1a, targeted by the autoimmune response. This novel autoantigen is expressed in the thymus in an Aire-dependent manner. The results from our study suggest that defects in central tolerance may contribute to SS and provide a new and clinically relevant model to investigate the pathogenic mechanisms in lacrimal gland autoimmunity and associated ocular surface sequelae.

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عنوان ژورنال:
  • Journal of immunology

دوره 184 8  شماره 

صفحات  -

تاریخ انتشار 2010